Endocrine Abstracts

Background: The 2017 World Health Organization classification of pituitary tumors established that, pituicytoma, granular cell tumor of the sella (GCT) and spindle cell oncocytoma (SCO) are posterior pituitary tumors (PPT). These lesions are non-neuroendocrine and low-grade neoplasms of the sellar region presenting with mass effect symptoms. Their clinical manifestation, hormonal profile and radiological findings are indistinguishable from non-functioning pituitary adenomas (N...

Pegvisomant (peg) is an effective treatment for acromegaly.Aim: To investigate the prevalence of escape and the incidence of lipodystrophy with peg treatment.Methods: Multicenter retrospective study. Escape was defined as loss of control in patients previously controlled under a stable dose of peg, without any other treatment change. Lipodystrophy was defined as either hypertrophy or atrophy of subcutaneous tissue in areas of drug ...

Pharmacologic treatment of acromegaly is currently based upon assay-error strategy in which first generation somatostatin analogs (SSA) is the first-line treatment. However, about 50% of patients do no respond adequately to SSA. We aimed to evaluate the potential usefulness of including studies of molecular markers identifying poor response to SSA for prescription of pharmacologic treatment in acromegalic patients in which SSA was prescribed before surgical therapy.<p clas...